Motif ID: TLX1..3_NFIC{dimer}.p2

Z-value: 2.336


Transcription factors associated with TLX1..3_NFIC{dimer}.p2:

Gene SymbolEntrez IDGene Name
TLX1 3195 T-cell leukemia homeobox 1
TLX3 30012 T-cell leukemia homeobox 3



Activity profile for motif TLX1..3_NFIC{dimer}.p2.

activity profile for motif TLX1..3_NFIC{dimer}.p2


Sorted Z-values histogram for motif TLX1..3_NFIC{dimer}.p2

Sorted Z-values for motif TLX1..3_NFIC{dimer}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TLX1..3_NFIC{dimer}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_27153892 3.256 NM_024014
HOXA6
homeobox A6
chrX_-_128616594 2.722 NM_017413
APLN
apelin
chr15_+_76889873 2.718 MORF4L1
mortality factor 4 like 1
chrX_-_53327473 2.443 NM_015075
IQSEC2
IQ motif and Sec7 domain 2
chr22_-_37970902 2.300 NM_002608
PDGFB
platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
chr5_+_38481392 2.241 NM_182801
EGFLAM
EGF-like, fibronectin type III and laminin G domains
chr19_+_10258642 2.182 NM_001039132
NM_001544
NM_022377
ICAM4


intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)


chr21_+_45699830 2.018 NM_030582
NM_130444
COL18A1

collagen, type XVIII, alpha 1

chr14_+_72773957 1.947 NM_173462
NDRG2
PAPLN
NDRG family member 2
papilin, proteoglycan-like sulfated glycoprotein
chr3_+_46717826 1.933 NM_147196
TMIE
transmembrane inner ear
chr1_-_151630168 1.924 NM_002964
S100A8
S100 calcium binding protein A8
chrX_-_129347101 1.850 NM_178471
GPR119
G protein-coupled receptor 119
chr1_+_219026661 1.848 NM_022746
MOSC1
MOCO sulphurase C-terminal domain containing 1
chr19_+_10404110 1.744 NM_001111309
PDE4A
phosphodiesterase 4A, cAMP-specific
chr17_-_928960 1.735 ABR
active BCR-related gene
chr22_+_40093245 1.670 NM_001145398
TEF
thyrotrophic embryonic factor
chr15_-_66511488 1.664 NM_001004439
ITGA11
integrin, alpha 11
chr9_+_135389698 1.653 NM_014694
ADAMTSL2
ADAMTS-like 2
chr6_+_167658563 1.632 NM_031949
TTLL2
tubulin tyrosine ligase-like family, member 2
chr17_+_75507750 1.618


chr11_+_74539679 1.602 NM_001145212
NM_007256
SLCO2B1

solute carrier organic anion transporter family, member 2B1

chrX_-_13866451 1.521 GPM6B
glycoprotein M6B
chr13_+_112670757 1.510 NM_001112732
MCF2L
MCF.2 cell line derived transforming sequence-like
chr19_-_38408449 1.449 NM_019849
SLC7A10
solute carrier family 7, (neutral amino acid transporter, y+ system) member 10
chr7_+_102340579 1.385 NM_001031692
NM_005824
LRRC17

leucine rich repeat containing 17

chr7_-_150283794 1.384 NM_172057
KCNH2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr1_+_78858675 1.368 NM_006820
IFI44L
interferon-induced protein 44-like
chr9_-_112010233 1.338 NM_001012993
C9orf152
chromosome 9 open reading frame 152
chrX_-_118168569 1.334 NM_020721
KIAA1210
KIAA1210
chr7_-_36991189 1.324 NM_001039459
ELMO1
engulfment and cell motility 1
chr19_+_51498695 1.318 NM_152794
HIF3A
hypoxia inducible factor 3, alpha subunit
chr1_-_41722883 1.316 NM_001956
EDN2
endothelin 2
chr3_+_127743868 1.240 CHST13
carbohydrate (chondroitin 4) sulfotransferase 13
chrX_-_13866366 1.239


chr22_-_29290875 1.218 NM_004861
GAL3ST1
galactose-3-O-sulfotransferase 1
chr1_+_183970093 1.217 NM_031935
HMCN1
hemicentin 1
chr17_-_74432671 1.213 TIMP2
TIMP metallopeptidase inhibitor 2
chrX_+_122922058 1.202 NM_001042749
STAG2
stromal antigen 2
chr14_+_69021149 1.194 NM_001161498
UPF0639
UPF0639 protein
chr19_+_3659358 1.181 TJP3
tight junction protein 3 (zona occludens 3)
chr7_-_99411573 1.173 NM_001185
AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr17_-_72045218 1.169 NM_134268
CYGB
cytoglobin
chrX_+_153423652 1.163 NM_001099856
IKBKG
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
chr8_-_18585721 1.154 PSD3
pleckstrin and Sec7 domain containing 3
chr16_+_56219802 1.150 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr15_-_81412354 1.142 NM_004839
NM_199330
NM_199331
NM_199332
HOMER2



homer homolog 2 (Drosophila)



chr3_-_58538110 1.142 FAM107A
family with sequence similarity 107, member A
chr19_+_15612706 1.100 NM_000896
CYP4F3
cytochrome P450, family 4, subfamily F, polypeptide 3
chr9_-_139183675 1.095


chrX_-_13866565 1.059 NM_001001994
GPM6B
glycoprotein M6B
chr8_-_27524744 1.059 NM_203339
CLU
clusterin
chr1_-_23683214 1.041 ASAP3
ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
chr7_+_142205266 1.019


chr1_-_245342150 0.994 NM_207401
C1orf229
chromosome 1 open reading frame 229
chr19_+_40849554 0.988 NM_007000
UPK1A
uroplakin 1A
chr2_+_108604111 0.986 NM_001193484
LIMS1
LIM and senescent cell antigen-like domains 1
chr16_-_30032330 0.974 NM_024307
GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chr11_-_118716736 0.955 C1QTNF5
MFRP
C1q and tumor necrosis factor related protein 5
membrane frizzled-related protein
chr6_-_43703024 0.939 GTPBP2
GTP binding protein 2
chrX_-_110541029 0.929 NM_000555
DCX
doublecortin
chr12_-_50871953 0.928 NM_001081492
NM_182507
KRT80

keratin 80

chr17_-_74433048 0.919 NM_003255
TIMP2
TIMP metallopeptidase inhibitor 2
chr6_-_43703057 0.905 GTPBP2
GTP binding protein 2
chr7_-_151205142 0.888 NM_016203
PRKAG2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr1_-_218168548 0.882 NM_018713
SLC30A10
solute carrier family 30, member 10
chr22_-_29197944 0.882 NM_174975
SEC14L3
SEC14-like 3 (S. cerevisiae)
chr3_+_52325374 0.880 NM_015512
DNAH1
dynein, axonemal, heavy chain 1
chr4_-_155632317 0.877 NM_001142552
NM_001142553
DCHS2

dachsous 2 (Drosophila)

chr17_-_74432800 0.854 TIMP2
TIMP metallopeptidase inhibitor 2
chr19_-_46048033 0.847 NM_000762
CYP2A6
cytochrome P450, family 2, subfamily A, polypeptide 6
chr3_+_42107711 0.845 NM_001042646
TRAK1
trafficking protein, kinesin binding 1
chr19_+_60035942 0.843 NM_012314
KIR2DS4
killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4
chrX_-_132947141 0.839 GPC3
glypican 3
chr7_-_143587653 0.837 NM_001005328
OR2A7
OR2A4
olfactory receptor, family 2, subfamily A, member 7
olfactory receptor, family 2, subfamily A, member 4
chrX_-_132947290 0.832 NM_001164617
NM_001164618
NM_001164619
NM_004484
GPC3



glypican 3



chr15_+_72828235 0.830 NM_000761
CYP1A2
cytochrome P450, family 1, subfamily A, polypeptide 2
chr22_+_43451351 0.810 NM_001017530
NM_001198721
NM_015366
PRR5


proline rich 5 (renal)


chr21_+_44761927 0.809 C21orf90
chromosome 21 open reading frame 90
chr20_+_34206070 0.804 NM_012156
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr19_+_51493486 0.793 NM_022462
HIF3A
hypoxia inducible factor 3, alpha subunit
chr8_-_27525084 0.787 NM_001171138
CLU
clusterin
chr16_+_2746363 0.780


chr19_-_8581559 0.780 NM_030957
ADAMTS10
ADAM metallopeptidase with thrombospondin type 1 motif, 10
chr10_+_685887 0.772 C10orf108
chromosome 10 open reading frame 108
chr1_-_1840564 0.768 NM_178545
TMEM52
transmembrane protein 52
chr10_+_26263163 0.761 MYO3A
myosin IIIA
chr1_-_199259133 0.760 KIF21B
kinesin family member 21B
chr9_+_130719034 0.760 LRRC8A
leucine rich repeat containing 8 family, member A
chr19_-_53950458 0.759 NM_000148
FUT1
fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
chr19_+_4442610 0.758 HDGFRP2
hepatoma-derived growth factor-related protein 2
chrX_-_114703273 0.753


chr1_-_199259447 0.751 NM_017596
KIF21B
kinesin family member 21B
chr17_-_4410565 0.750 NM_001122890
NM_153338
GGT6

gamma-glutamyltransferase 6

chr6_+_29663661 0.741 NM_007160
OR2H2
olfactory receptor, family 2, subfamily H, member 2
chr6_-_3390197 0.736 NM_021945
SLC22A23
solute carrier family 22, member 23
chr1_-_111848265 0.735 NM_000677
NM_020683
ADORA3

adenosine A3 receptor

chr6_-_30236667 0.734 NM_006778
NM_052828
TRIM10

tripartite motif containing 10

chr17_-_4491694 0.730 NM_001140
ALOX15
arachidonate 15-lipoxygenase
chr13_-_24643620 0.726 FAM123A
family with sequence similarity 123A
chr20_+_41628150 0.725 NM_016276
SGK2
serum/glucocorticoid regulated kinase 2
chr1_-_227636462 0.707 NM_001100
ACTA1
actin, alpha 1, skeletal muscle
chr7_+_142723340 0.707 NM_000083
CLCN1
chloride channel 1, skeletal muscle
chr17_-_77394872 0.701 P4HB
prolyl 4-hydroxylase, beta polypeptide
chr16_+_55456619 0.701 NM_000339
NM_001126107
NM_001126108
SLC12A3


solute carrier family 12 (sodium/chloride transporters), member 3


chr19_+_59973074 0.700 NM_014218
KIR2DS2
KIR2DL1
killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2
killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
chr11_-_35397675 0.696 NM_004171
SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr1_+_151015471 0.696 NM_178354
LCE1F
late cornified envelope 1F
chr1_+_61319976 0.694 NM_001145512
NFIA
nuclear factor I/A
chr12_-_47031287 0.692 NM_001172682
ZNF641
zinc finger protein 641
chr11_+_119616112 0.683 NM_014352
POU2F3
POU class 2 homeobox 3
chr2_+_26924466 0.682 NM_020134
DPYSL5
dihydropyrimidinase-like 5
chr9_-_139184247 0.681 NM_001013653
LRRC26
leucine rich repeat containing 26
chrX_+_106048245 0.676 NM_001171095
CLDN2
claudin 2
chr4_+_86968069 0.676 ARHGAP24
Rho GTPase activating protein 24
chr17_+_24394043 0.669 NM_016518
PIPOX
pipecolic acid oxidase
chr17_-_44226595 0.668 NM_173623
TTLL6
tubulin tyrosine ligase-like family, member 6
chrX_+_106057984 0.667 CLDN2
claudin 2
chrX_+_152423277 0.667 BGN
biglycan
chrX_+_133952633 0.657 NM_001163438
LOC644538
hypothetical protein LOC644538
chr9_-_123302126 0.657 GGTA1
glycoprotein, alpha-galactosyltransferase 1 pseudogene
chr5_-_176763991 0.654 F12
coagulation factor XII (Hageman factor)
chr17_+_7125702 0.652 NM_001042
SLC2A4
solute carrier family 2 (facilitated glucose transporter), member 4
chr1_-_92722088 0.652 GFI1
growth factor independent 1 transcription repressor
chr9_-_23811842 0.650 NM_001171195
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr1_+_116181927 0.645 NHLH2
nescient helix loop helix 2
chr8_+_55533047 0.642 NM_022454
SOX17
SRY (sex determining region Y)-box 17
chr16_-_49742651 0.642 NM_002968
SALL1
sal-like 1 (Drosophila)
chr2_+_242400702 0.641 NM_001167599
NM_001167602
NM_080741
NEU4


sialidase 4


chr22_+_21065202 0.640


chr5_-_36278000 0.637 NM_153013
C5orf33
chromosome 5 open reading frame 33
chr14_+_105063975 0.634 NM_025268
TMEM121
transmembrane protein 121
chr20_+_55569542 0.633 NM_002591
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr7_+_128142661 0.631 NM_032599
FAM71F1
family with sequence similarity 71, member F1
chr10_+_82163568 0.629 C10orf58
chromosome 10 open reading frame 58
chr14_-_104142125 0.629 NM_207379
TMEM179
transmembrane protein 179
chr10_+_135010833 0.627 NM_001145201
NM_145202
PRAP1

proline-rich acidic protein 1

chr3_-_11585264 0.626 NM_001128221
VGLL4
vestigial like 4 (Drosophila)
chr11_-_30564338 0.621 NM_001145399
MPPED2
metallophosphoesterase domain containing 2
chr17_+_24394281 0.610 PIPOX
pipecolic acid oxidase
chr3_+_42675841 0.610 ZBTB47
zinc finger and BTB domain containing 47
chr9_+_138726737 0.609 NM_152421
FAM69B
family with sequence similarity 69, member B
chr5_+_176449156 0.606 NM_022963
FGFR4
fibroblast growth factor receptor 4
chr22_+_21065134 0.605 LOC100290481
immunoglobulin lambda light chain-like
chr17_+_4795128 0.604 NM_001193503
NM_001976
NM_053013
ENO3


enolase 3 (beta, muscle)


chr15_+_64781723 0.602 NM_005585
SMAD6
SMAD family member 6
chr1_-_218168404 0.602


chr1_+_16247870 0.602 NM_001165945
CLCNKB
chloride channel Kb
chr11_-_69299351 0.601 NM_002007
FGF4
fibroblast growth factor 4
chr1_-_151804929 0.599 NM_005978
S100A2
S100 calcium binding protein A2
chr6_-_28429950 0.599 NM_145909
ZNF323
zinc finger protein 323
chr10_-_51156329 0.599 NM_001077685
AGAP4
AGAP7
ArfGAP with GTPase domain, ankyrin repeat and PH domain 4
ArfGAP with GTPase domain, ankyrin repeat and PH domain 7
chr16_-_19803606 0.593 NM_016235
GPRC5B
G protein-coupled receptor, family C, group 5, member B
chr12_-_4425040 0.579 NM_020996
FGF6
fibroblast growth factor 6
chr19_+_49894260 0.578 NM_001039213
CEACAM16
carcinoembryonic antigen-related cell adhesion molecule 16
chr1_+_18680010 0.577 NM_152375
KLHDC7A
kelch domain containing 7A
chr9_+_138991775 0.574 NM_000954
PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr8_-_145672525 0.573 NM_003923
FOXH1
forkhead box H1
chr11_-_33870411 0.569 NM_005574
LMO2
LIM domain only 2 (rhombotin-like 1)
chr6_-_39305203 0.566 NM_003740
KCNK5
potassium channel, subfamily K, member 5
chr16_-_3025542 0.563 NM_001103175
CCDC64B
coiled-coil domain containing 64B
chr1_-_92721943 0.562 NM_001127215
GFI1
growth factor independent 1 transcription repressor
chr11_-_56846246 0.562 TNKS1BP1
tankyrase 1 binding protein 1, 182kDa
chr1_-_158306570 0.558 NM_002241
KCNJ10
potassium inwardly-rectifying channel, subfamily J, member 10
chr17_-_4747147 0.557 NM_000080
CHRNE
cholinergic receptor, nicotinic, epsilon
chr3_+_38007264 0.556 VILL
villin-like
chr20_+_43468046 0.556 NM_001197139
NM_001048221
NM_001048222
NM_001197140
NM_018478
DBNDD2




dysbindin (dystrobrevin binding protein 1) domain containing 2




chr19_-_40325194 0.553 LGI4
leucine-rich repeat LGI family, member 4
chr11_-_10672079 0.553 NM_001100163
NM_130385
MRVI1

murine retrovirus integration site 1 homolog

chrX_-_54841397 0.551 NM_198510
ITIH5L
inter-alpha (globulin) inhibitor H5-like
chr11_-_35397090 0.549 SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chrX_-_8660170 0.549 NM_000216
KAL1
Kallmann syndrome 1 sequence
chr12_+_99391681 0.549 NM_005123
NR1H4
nuclear receptor subfamily 1, group H, member 4
chr22_+_21065207 0.549 IGLJ3
immunoglobulin lambda joining 3
chr6_-_68655708 0.538


chrX_-_40391610 0.537 CXorf38
chromosome X open reading frame 38
chr3_-_127558747 0.535 NM_014079
KLF15
Kruppel-like factor 15
chrX_-_71268475 0.535 NM_001024455
RGAG4
retrotransposon gag domain containing 4
chrX_+_2756810 0.534 NM_001079855
NM_001184702
NM_001184703
NM_001184704
NM_003918
GYG2




glycogenin 2




chr8_-_22841173 0.534 NM_144962
PEBP4
phosphatidylethanolamine-binding protein 4
chr9_+_138991835 0.530 PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr1_-_86394695 0.530 NM_152890
COL24A1
collagen, type XXIV, alpha 1
chr19_+_15644885 0.524 NM_023944
CYP4F12
cytochrome P450, family 4, subfamily F, polypeptide 12
chr16_+_273118 0.521 NM_006849
PDIA2
protein disulfide isomerase family A, member 2
chr1_-_156078115 0.521 NM_005894
CD5L
CD5 molecule-like
chr11_-_117600918 0.519 NM_001098526
AMICA1
adhesion molecule, interacts with CXADR antigen 1
chr11_-_1973319 0.518 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr13_+_97593411 0.517 NM_001001715
NM_005766
FARP1

FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)

chr10_-_105604942 0.515 NM_014631
SH3PXD2A
SH3 and PX domains 2A
chr11_-_64266916 0.514


chr16_+_2071631 0.514 TSC2
tuberous sclerosis 2
chr2_-_96314148 0.513 SNRNP200
small nuclear ribonucleoprotein 200kDa (U5)
chr11_-_118757574 0.512 NM_004205
USP2
ubiquitin specific peptidase 2
chr1_+_78888064 0.511 NM_006417
IFI44
interferon-induced protein 44
chr6_+_132170888 0.511 ENPP1
ectonucleotide pyrophosphatase/phosphodiesterase 1
chr22_+_18085990 0.508 SEPT5-GP1BB
SEPT5
SEPT5-GP1BB read-through transcript
septin 5
chr4_-_66218777 0.506 EPHA5
EPH receptor A5
chr10_+_26263007 0.503 NM_017433
MYO3A
myosin IIIA
chr12_-_24947233 0.500 NM_001178093
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr9_-_23811477 0.498 NM_001171197
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr22_-_40666168 0.498 NM_001110215
CENPM
centromere protein M

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
4.10 3.47e-03 GO:0044421 extracellular region part
7.05 3.74e-03 GO:0031012 extracellular matrix
7.15 1.26e-02 GO:0005578 proteinaceous extracellular matrix
2.65 3.19e-02 GO:0005576 extracellular region

Nothing significant found in function category.